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Expression Patterns of Cell Adhesion Molecules on CD4+ T Cells and WC1+ T Cells in the Peripheral Blood of Dromedary Camels
 
Jamal Hussen1*, Turke Shawaf2, Abdulkareem Imran. Al-herz3, Hussain R. Alturaifi3, Mohammad H Al khamees4 and Ahmed M Alluwaimi1
 
1Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Al Ahsaa, Saudi Arabia; 2Department of Clinical Studies, College of Veterinary Medicine, King Faisal University, Al Ahsaa, Saudi Arabia
3Immunology Unit, Diagnostic Laboratory and Blood Bank, King Fahad Hospital Hufof, Al Ahsaa, Saudi Arabia
4Immunology and Serology Unit, Department of Laboratory and Blood Bank, Maternity and Children Hospital, Al Ahsaa, Saudi Arabia; *Corresponding author: jhussen@kfu.edu.sa; jalhussen@gmail.com
 

Abstract   

In human, mice and different veterinary species, T cells are subdivided into phenotypically different subpopulations based on their expressed T cell receptor and cell specific surface markers. As no data were available regarding the existence of T cell subpopulations in the peripheral blood of dromedary camels, the current study aimed at the identification of camel blood T cell subpopulations and the analysis of their adhesion molecules expression patterns. Using monoclonal antibodies cross-reactive with camel CD antigens, camel blood WC1-positive T cells and CD4-positive ab T cells and their expression pattern of adhesion molecules were identified by flow cytometry. Under camel CD4-positive T cells, a major fraction (83%) with naïve phenotype (CD4+ CD11alo CD44lo) and minor fraction (13%) with effector phenotype (CD4+ CD11ahi CD44hi) were identified. In addition, the analysis of age related effects on the proportion of lymphocyte subsets indicates that camels belong to the T cell high species.

To Cite This Article: Hussen J, Shawaf T, Al-herz AI, Alturaifi HR, Al Khamees MH and Alluwaimi AM, 2018. Expression patterns of cell adhesion molecules on CD4+ T cells and WC1+ T cells in the peripheral blood of dromedary camels. Pak Vet J. http://dx.doi.org/10.29261/pakvetj/2018.055

 
   

ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)



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