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Garcinia Mangostana Extract Enhances Skin Epithelialization in Rat Induced Burn Injury
Marisca Evalina Gondokesumo1,2#, Bambang Pardjianto3, Kusworini Handono4, Sutiman Bambang Sumitro5, Wahyu Widowati6, Okta Wismandanu7, Tyagita Hartady7, Aziiz Mardanarian Rosdianto7, Hanna Goenawan7,8,9, Ronny Lesmana7,8,9, Nasrul Wathoni10 and Unang Supratman9,11
1Biomedical Sciences Doctoral Study, Faculty of Medicine, Brawijaya University, Malang, Indonesia; 2Faculty of Pharmacy, University of Surabaya, Surabaya, East Java, Indonesia; 3Departement of Plastic Surgery, Saiful Anwar General Hospital, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia; 4Department of Clinical Pathology, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia.5Biology Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia; 6Faculty of Medicine, Maranatha Christian University, Bandung, Indonesia; 7Veterinary Medicine Study Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 8Physiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Indonesia; 9Division of Biological Activity, Central Laboratory, Universitas Padjadjaran, Indonesia; 10Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia; 11Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas  Padjadjaran, Bandung, Indonesia.
*Corresponding author:


Mangosteen has several important elements for biological activities such as anti-oxidant, anti-inflammatory, anti-bacterial and anti-cancer. There are γ-mangostin, α-mangostin, flavonoids, saponins, and tannins which could stimulate the collagen deposition and accelerate wound healing process. Burn injury cause deep wound in the skin and often cause cicatrix and keloid scar on the skin. However, there is limited information about role of mangosteen in skin wound healing after burn injury. Fifty 10 week-old male rats, were subjected to burn injury using automatic temperature control. Burn injury was created by direct contact of hot plate (170°C) for 15 seconds on rats’ inter scapula region. We elaborate the role of extract mangosteen in skin wound healing by applying daily gel contain with active compound derived from mangosteen. There was no significant weight change during treatment period. We observed that there was significant increase of Epidermal Growth Factors (EGF) expression in 14 as shown in Immunohistochemistry and confirmed by western blot protein results. Taken together, mangosteen peel extract-mediated changes in the expression of growth factors in burned rat skins. mangosteen peel extract might have a role in the acceleration of skin wound healing.

To Cite This Article: Gondokesumo ME, Pardjianto B, Handono K, Sumitro SB, Widowati W, Wismandanu O, Goenawan H, Hartady T, Rosdianto AM, Lesmana R, Wathoni N and Supratman U, 2019. Garcinia Mangostana extract enhances skin epithelialization in rat induced burn injury. Pak Vet J.


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)