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Neuroprotective Effects of Clove Oil in Acrylamide Induced Neurotoxicity in Rats
Mohamed Aboubakr1*, Samar Saber Ibrahim2, Alshaimaa Mohamed Said 3, Fatma Elgendey4 and Anis Anis5
1Pharmacology Department; 2Forensic Medicine and Toxicology Department; 3Biochemistry Department; 4Animal Wealth Development Department, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt; 5Pathology Department, Faculty of Veterinary Medicine, University of Sadat City, Menoufiya, Egypt; *Corresponding author:


Clove oil (CO) is known for its antioxidant properties and has great potential for pharmaceutical, food, cosmetic and agricultural uses. Acrylamide (AA) as a potent neurotoxic agent and human exposure to AA involves dietary intake of carbohydrates processed at high temperature. This study evaluated if CO administration could protect against neurotoxicity induced by AA in rats. The rats were grouped into five groups, (I) control (corn oil), (II) AA (20 mg/kg BW), (III) CO (200 mg/kg BW), (IV) CO (100 mg/kg BW) in addition to AA (20 mg/kg BW) and (V) CO (200 mg/kg BW) in addition to AA (20 mg/kg BW). All treatments were administered for 21 days. AA produced oxidative stress and DNA damage in brain. The neuroprotective effects of CO which reverse the oxidative stress in rats treated with AA; increasing GSH, SOD and decreasing MDA levels. Moreover, it decreases the level of GABA, while it increases the AChE level returning all parameters towards normal levels. AA treatment induce a wide spread degeneration/ necrosis in pyramidal neurons of CA3 region and neurons of granular layer (GL) of rat hippocampus. CO could minimize AA-induced neurotoxicity by attenuating oxidative brain injuries.

To Cite This Article: Aboubakr M, Ibrahim SS, Said AM, Elgendey F and Anis A, 2018. Neuroprotective effects of clove oil in acrylamide induced neurotoxicity in rats. Pak Vet J.


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)