PAKISTAN
VETERINARY
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Emergence of blaNDM-5-producing Escherichia coli ST410 in Companion Dogs Treated with Meropenem
 
JY Oh1, S Sum1, WK Song2, JC Chae3and HM Park1*
 
1Department of Veterinary Internal Medicine, Konkuk University College of Veterinary Medicine, Seoul, South Korea
2Department of Laboratory Medicine, Hallym University College of Medicine, Chuncheon, South Korea
3Division of Biotechnology, Chonbuk National University, Iksan, South Korea
*Corresponding author: parkhee@konkuk.ac.kr

Abstract   

Carbapenem-resistant Escherichia coli (CRE) with a multidrug resistant phenotype was isolated from four clinically ill dogs treated with meropenem in different local animal hospitals between 2017 and 2019. IncX3-type plasmids of ca. 46 kb in size carrying blaNDM-5 were present in all CRE strains and their transconjugants. High genetic similarity (>90%) by PFGE analysis was observed among the CRE strains, which were identified as ST410.To the best of our knowledge, blaNDM-5-producing E. coli ST410 clones are emerging sporadically in companion dogs treated with meropenem. The spread of Enterobacteriaceae harboring the NDM-5 gene in companion animals can pose a threat to public health; therefore, extensive monitoring in veterinary hospitals using carbapenem and careful antibiotic use are crucial for managing and monitoring these resistant strains.

To Cite This Article: Oh JY, Sum S, Song WK, Chae JC and Park HM, 2020. Emergence of blaNDM-5-producing Escherichia coli ST410 in companion dogs treated with meropenem. Pak Vet J. http://dx.doi.org/10.29261/pakvetj/2020.073

 
   

ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)



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