PAKISTAN
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Alteration of Serum Cystatin-C Levels after Hemodialysis in Dogs with Kidney Disease
 
Woonchan Ahn1,2, Tae Hyeong Kim3, Taeho Lee2, Jin-Ok Ahn1, Jung Hoon Choi3 and Jin-Young Chung1, *
 
1Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, 1 Kangwondaehak-gil, Chuncheon-si, 24341, Gangwon-do, South Korea
2Smart animal hospital Sinsa, Seoul, 06026, Korea; 3Department of Veterinary Anatomy, College of Veterinary Medicine, Kangwon National University, 1 Kangwondaehak-gil, Chuncheon-si, 24341, Gangwon-do, South Korea
*Corresponding author: jychung77@gmail.com

Abstract   

Kidney diseases are common life-threatening diseases in small animals. To evaluate the efficiency of hemodialysis in kidney disease treatment, several low-molecular-weight biochemical markers can be assessed. Recently, middle-molecular-weight proteins such as cystatin-C have been investigated for use as alternative biomarkers to evaluate renal function and predict mortality, especially in human hemodialysis patients. The goal of this study is to assess changes in cystatin-C levels when performing low-flux hemodialysis with an ultraflux dialyzer in dogs with kidney disease. This was a retrospective study. A total of twenty hemodialysis sessions were included in the study. The concentrations of cystatin-C level before and after hemodialysis were determined by examining ELISA results. The cystatin-C concentration was significantly lower after hemodialysis than before hemodialysis (P=0.0016). Cystatin-C can be removed by using low-flux hemodialysis. Thus, cystatin-C can be considered a potential kidney function biomarker in dogs with kidney disease being treated with low-flux intermittent hemodialysis.

To Cite This Article: Ahn W, Kim TH, Lee T, Ahn JO, Choi JH and Chung JY, 2020. Alteration of serum cystatin-c levels after hemodialysis in dogs with kidney disease. Pak Vet J. http://dx.doi.org/10.29261/pakvetj/2020.100

 
   

ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)



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