PAKISTAN
VETERINARY
JOURNAL
     
 
previous page   Pak Vet J, xxxx, xx(x): xxx-xxx   next page
 
Evaluation of Antibacterial Potential of Raw Turmeric, Nano-Turmeric, and NSAIDs against MDR Staphylococcus aureus and E. coli Isolated from Animal Wounds
 
Iqra Sarwar1, Ambreen Ashar1, Ashar Mahfooz1*, Amjad Islam Aqib2, Muhammad Ijaz Saleem1, Asif Ali Butt3, Zeeshan Ahmed Bhutta1, Muhammad Shoaib4, Muhammad Fakhar-e-Alam Kulyar1 and Athar Ilyas5
 

1Department of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, 38000, Pakistan; 2Department of Medicine, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, 63100, Pakistan; 3Riphah International University, Faisalabad, 44000, Pakistan; 4Institute of Microbiology, University of Agriculture, Faisalabad, 38000, Pakistan; 5Department of Theriogenology, University of Agriculture, Faisalabad, 38000, Pakistan
*Corresponding author: drasharcms@gmail.com

Abstract   

Wound healing gets difficult due to antibiotic resistance and requires prolong therapy. Current study was planned to check antibacterial potential of raw turmeric, nano-turmeric, and Non-steroidal anti-inflammatory drugs against MDR Staphylococcus aureus and E. coli isolated from animal wounds. Wound samples (n=150) were collected from different animals. Isolation and confirmation of S. aureus and E. coli was done by microbiological techniques and biochemical tests. Confirmed isolates were subjected to number of antibiotics for MDR S. aureus and E. coli. Drug modulation of MDR isolates were done by NT, RT, and NSAIDs in combination with antibiotics using well diffusion method. The data were analyzed by non-probability testing at 5% probability using SPSS statistical computer program. Study found 20.7% and 28.7% of MDR E. coli and S. aureus from animal wounds, respectively. MDR S. aureus were found 27.40, 33.30, and 100% sensitive while MDR E. coli were found 12.50, 62.50, and 75.00% against oxytetracycline, chloramphenicol, and trimethoprim-sulphamethoxozole, respectively. Nano curcumin showed higher antibacterial activity against MDR S. aureus and E. coli in comparison with raw curcumin. NSAIDs in combination with antibiotic also showed synergistic effect in inhibition of bacterial growth. Among the assumed risk factors external parasites, body condition and antibiotic use showed significant association. The study found higher prevalence of MDR S. aureus and E. coli from wounds with significant association of assumed risk factors, along with promising antibacterial effects of nano curcumin, raw curcumin, and NSAIDs in combination with antibiotics.

To Cite This Article: Sarwar I, Ashar A, Mahfooz A, Aqib AI, Saleem MI, Butt AA, Bhutta ZA, Shoaib M, Kulyar MFA and Ilyas A, xxxx. Evaluation of antibacterial potential of raw turmeric, nano-turmeric, and NSAIDs against MDR Staphylococcus aureus and E. coli isolated from animal wounds. Pak Vet J. http://dx.doi.org/10.29261/pakvetj/2021.014

 
   

ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)



scopus
 
DOI
 
DOAJ SEAL