PAKISTAN
VETERINARY
JOURNAL
     
 
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Changes in Immune Cell Composition During the Periparturient Period in Female Dromedary Camels
 
Jamal Hussen1*, Abdullah IA Al-Mubarak1, Naser Abdallah Al Humam1, Turke Shawaf2 and Faisal Almathen3,4
 
1Department of Microbiology, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia
2Department of Clinical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia
3Department of Veterinary Public Health, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia; 4The Camel Research Center, King Faisal University, Al-Ahsa, Saudi Arabia
*Corresponding author: jhussen@kfu.edu.sa

Abstract   

In the dromedary she-camel, the impact of parturition on composition and phenotype of blood immune cells has not been evaluated so far. Therefore, the current study aimed to investigate the composition of blood leukocytes and their cell adhesion molecules expression in she-camels during the periparturient period. Using flow cytometry and membrane immunofluorescence, leukocyte composition and adhesion molecules expression were analyzed in blood samples collected from she-camels at days -28, -14, 0, +14 and +28 relative to calving. At parturition, she-camels showed a significant rise in the number of total leukocytes with increased numbers of neutrophilic granulocytes. Two weeks after calving, the number of total lymphocytes was significantly elevated. Among lymphocytes, the numbers of CD4+ T cells and B cells were expanded. Although the cell number of total monocytes did not change significantly during the periparturient period, significant differences in the fractions of monocyte subsets were observed. The number of the CD14high MHCIIlow monocyte subset significantly decreased at calving and remained at a low abundance during the postparturient time, while the numbers of the CD14high MHCIIhigh and the CD14low MHCIIhigh monocyte subsets increased after calving. For neutrophils (at calving and at day +14 after calving) and monocytes (at calving), a significant increase in the expression of the cell adhesion molecule CD11a was observed. Collectively, the present study identified several alterations in the leukogram and distribution of blood monocyte and lymphocyte subpopulations during the periparturient period in dromedary she-camels.

To Cite This Article: Hussen J, Al-Mubarak AIA, Al Humam NA, Shawaf T and Almathen F, xxxx. Changes in immune cell composition during the periparturient period in female dromedary camels. Pak Vet J. http://dx.doi.org/10.29261/pakvetj/2021.004

 
   

ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)



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