PAKISTAN
VETERINARY
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Immunogenicity and Protective Efficacy of Probiotics with EtIMP1C against Eimeria tenella Challenge
 
Muhammad Mohsin1,2,3*, Lina Li1, Xiaohang Huang1, Muhammad Tahir Aleem3,5, Yusuf Jibril Habib1,2, Akram Ismael Shehata1,2, Muhammad Zeeshan Afzal4, Rao Zahid Abbas3, Asghar Abbas6* and Guangwen Yin1*
 

1College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou, Fujian Province, 350002, China; 2College of Life Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian Province, 350002, China; 3Department of Parasitology, University of Agriculture, Faisalabad, Pakistan; 4Department of Pathology, University of Agriculture, Faisalabad, Pakistan; 5MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China; 6Department of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan
*Corresponding authors: yinguangwen000@sina.com; onlymohsindvm@gmail.com; asghar.abbas@mnsuam.edu.pk

Abstract   

Coccidiosis is an endemic problem in broilers inflicting disastrous losses to worldwide poultry industry. Vaccines are generally effective in controlling the infectious diseases; the subunit vaccines effectiveness can hopefully be improved with concurrent use of probiotics as assessed in this experiment using an Eimeria tenella challenge. Immune mapped protein-1 (IMP1) is a novel immunogenic protein of Apicomplexans, including in Eimeria tenella. Anticoccidial performance of the cumulative effect of probiotics and EtIMP1C (Part of Eimeria tenella immune mapped protein1) was evaluated based on various parameters such as an intestinal lesion, oocyst scores, feed conversion ratio, and organ weight. Data were also analyzed on both immunological and hematological parameters. The EtIMP1C and probiotics administered group showed less intestinal lesion, decreased oocyst shedding, satisfactory feed conversion ratio (FCR) and improved hematological parameters as compared to EtIMP1C emulsified with FCA group. However, there was no statistically significant difference between the two groups (P>0.05), in aspect of lesion and oocyst scores, as well as immunological and hematological parameters. The experimental work showed that probiotics could be a good hope due to its antioxidant, immunomodulatory and gro­­­­­­­­­­­­­wth promoting effect against poultry coccidiosis alone or in combination with vaccines, including IMP1C based vaccine, but further studies are required to formulate its dose with the vaccine as well as a different strain of probiotics effect against coccidiosis.

To Cite This Article: Mohsin M, Li L, Huang X, Aleem MT, Habib YJ, Shehata AI, Afzal MZ, Abbas RZ, Abbas A and Yin G, xxxx. Immunogenicity and protective efficacy of probiotics with EtIMP1C against Eimeria tenella challenge. Pak Vet J. http://dx.doi.org/10.29261/pakvetj/2021.009

 
   

ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)



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