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Ameliorating Effect of Lycopene and N-Acetylcysteine against Cisplatin-Induced Cardiac Injury in Rats
 
Asmaa Elsayed1, Ashraf Elkomy1, Mohamed Alkafafy2, Reda Elkammar3, Sabreen Ezzat Fadl4, Ehab Yahya Abdelhiee5, Ahmed Abdeen6, Gehan Youssef6, Hassan Shaheen7, Ahmed Soliman8 and Mohamed Aboubakr1*
 

1Department of Pharmacology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt; 2Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
3Department of Histology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt; 4Biochemistry Department, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt
5Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt
6Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, 13736 Moshtohor, Toukh, Qaliobiya, Egypt; 7atco Pharma for Pharmaceutical Industry, Industrial Quisna Zone, ElMenofia, Egypt; 8Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, 12211 Giza, Egypt
*Corresponding author: mohamed.aboubakr@fvtm.bu.edu.eg

Abstract   

Cisplatin (CP) is one of antineoplastic agents with a broad range of anticancer activities.  This research investigated the possible protective effects of lycopene (LP) and N acetylcysteine (NAC) in rats against CP-induced cardiac toxicity. Seven groups of rats (n=7); control vehicle group was administered saline, LP (10 mg/kg, PO), NAC (150 mg/kg, PO), CP group (7.5 mg/kg, IP) on the 27th day of the experiment, LP-CP group, NAC-CP group, and LP-NAC-CP group. Following injection of CP, concentrations of cardiac biomarkers, lactate dehydrogenase (LDH), creatine kinase (CK) and creatine kinase MB (CK-MB) were increased in serum of the treated groups.  In addition, CP resulted in a significant increase in malondialdehyde (MDA), as well as significant decreases in glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in rats' heart tissues. CP resulted in changes in cardiac histopathology and increased caspase-3 expression in cardiac tissues. Administration of LP and/or NAC ameliorated cardiac toxicity and apoptosis induced by CP, through their antioxidant properties.

To Cite This Article: Elsayed A, Elkomy A, Alkafafy M, Elkammar R, Fadl SE, Abdelhiee EY, Abdeen A, Shaheen H, Soliman A and Aboubakr M, 2021. Ameliorating effect of lycopene and N-acetylcysteine against cisplatin-induced cardiac injury in rats. Pak Vet J. http://dx.doi.org/10.29261/pakvetj/2021.035

 
   

ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)



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