THERAPEUTIC DRUG TRIAL IN ALBINO MICE AGAINSTTRYPANOSOMIASIS
S.
Ahmad, A. A. Nasir and A.H. Awan
Veterinary
Research Institute,
Ghazi Road,
LahoreCantt,
Pakistan
Abstract
This study was conducted to determine the trypanocidal efficacy of Antrycide,
Fatrybanil and Trypamedium in albino mice experimentally infected sub-cutaneously
with Trypanosoma evansi. For this purpose, 25 albino mice were randomly
divided into five equal groups i.e. A, B, C, D and E. Groups A, B and C were
infected andthen treated with
Antrycide, Fatrybanil and Trypamedium, respectively. Group D was kept as
infected and group E non-infected control. On the basis of blood smear
examination, the efficacy of Antrycide and Fatrybanil was found 100% when used
in single dose as compared to Trypamedium which was 100% effective with second
dose.