INVESTIGATION OF THE TOXICITY POTENTIAL OF
TRIGONELLA FOENUM GRAECUM (LINN)
K.D. Effraim, T.W. Jaxks and P.A. Nwafor
Department of Pharmacology,
College of Medical Sciences, University of Maiduguri,
Maiduguri,
Borno State, Nigeria
Abstract
Extract prepared from the seeds of Trigonella
foenum graecum Linn, was administered twice a week for four weeks, at dosages of
1.0, 1.5 and 2.0 gkg-1 body weight, to male albino Wistar rats. At
the end of fourth week, the animals were sacrificed by transaction of the
jugular vein and testes, kidneys and liver of each rat were processed for
histopathological assessment. The extract of Trigonella foenum gruecum at all
dose levels, had necrotic effect on the liver and the kidney tissues.
Spermatogenesis was observed in the testes at dosage levels of 1.5 gkg-1
and 2.0 gkg-1 of the extract.