Abstract   

    In vitro binding of sulfamerazine with the plasma protein of buffaloes, cows, sheep and goats was studied. The binding in buffaloes ranged between 51.9 to 64.5 percent, cows 66.7 to 70.4, sheep 61.9 to 67.7 and in goats 63.7 to 75.2 percent at concentrations of drugs ranging between 50 to 250 µg/ml. Plasma pH affected the binding, being lower at higher pH values and vice versa. When total amount of protein in plasma was decreased the amount of bound drug decreased and vice versa. The studies indicate that binding of sulfamerazine to plasma protein was affected by the drug concentration in plasma, plasma pH, and total proteins.    

Key words: Sulfamerazine, plasma protein, buffaloes, cows, sheep, goats.