POST INFECTION DISSEMINATION PATTERN OF AVIAN
ADENO-VIRUS INVOLVED IN HYDROPERICARDIUM SYNDROME
K. Naeem, A. Rahim1 and I.U. Majeed
Animal Sciences Institute, National Agricultural
Research Centre,
Park Road,
Islamabad; 1Quaid-i-Azam
University,
Islamabad,
Pakistan
Abstract
To determine the post-infection tissue
dissemination pattern of Avian Adenovirus-4 (AA V-4), the virus was inoculated
in broilers via subcut or oral routes. The birds were sacrificed at 12 hour
interval and their organs were examined by indirect fluorescent antibody (IFA)
assay for the presence of viral antigen. A distinct variation in the virus
retention pattern in different organs of the inoculated birds was observed, Both
the kidneys and liver in the inoculated birds showed the persistence of AA V-4
beyond 60 hours post inoculation. Histopathological studies revealed basophilic
intranuclear inclusions in liver and kidneys, and also showed a low level of
inflammatory cell infiltration in these organs.
Key words: Avian Adeno-virus, hydropericardium syndrome,
post infection, dessemination pattern.