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COMPARATIVE PHARMACOKINETIC STUDIES ON OXYTETRACYCLINE IN CAMELS, SHEEP AND GOATS

Mohammed H. Al-Nazawi

Department of physiology, biochemistry and pharmacology, College of Veterinary Medicine and Animal Resources, King Faisal University, P. O. Box 3498, Al-Ahsa 31982, Saudi Arabia.

Abstract

    Kinetics of long-acting oxytetracycline (OTC) injected intravenously (IV) at a dose of 5 mg/kg was determined in each of eight camels, sheep and goats. The disposition of OTC was described by two-compartment open model. Two elimination half-lives were recorded for the camel (81 min and 46.1 h), whereas in sheep and goats these were 3.2 and 3.4 h, respectively. The peak plasma concentration was 10.2, 850 and 780 mg/ml at 5 minutes in camel, sheep and goats, respectively. The values of volume of distribution were 1.4, 13.4 and 12.1 litre/kg for the camels, sheep and goats, respectively. In sheep and goats, values of t1/2, Vd and clearance were found similar but different from camel, indicating exclusive distribution and substantial storage which were consistent with oxytetracycline lipophilicity and the large fat content of camel body.

Key words: Camel, goat, sheep, Pharmacokinetics, oxytetracycline
 
   

ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)



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