Organ to body weight ratio in chickens is considered to be an important parameter to study the immune status due to any infection or vaccination. The present paper reports the effects of local gametocyte and Livacox vaccines on live weight gains and lymphoid organs in chickens. The mean body weight gains in chickens with local gametocytes vaccine were significantly better (P<0.05) than in chickens with Livacox vaccine. Higher organ to body weight ratio was recorded in vaccinated chickens compared to control, although difference was non significant. Organ to body weight ratio of the lymphoid organs had higher values in chickens vaccinated with Livacox compared to local gametocyte vaccinated group, the difference was also found to be non significant. It was concluded that local gametocyte vaccine significantly increased the body weights of chickens compared to Livacox and control groups.