COMPARATIVE ANAESTHETIC EFFICACY OF PROPOFOL, THIOPENTAL SODIUM AND COMBINATION
OF PROPOFOL WITH KETAMINE HYDROCHLORIDE IN DOGS
N. MUHAMMAD, M. A. ZAFAR, G. MUHAMMAD, M. Z. MASOOD, A. MANZOOR AND
I.
SARFARAZ
Department of Clinical Medicine and Surgery,
University
of Agriculture,
Faisalabad,
Pakistan
Abstract
The present study was undertaken to determine the
comparative efficacy of propofol alone at two dosages, thiopental sodium and
propofol in combination with ketamine hydrochloride in dogs. For this purpose,
24 healthy stray dogs were randomly divided into four equal groups viz. A, B, C
and D. Groups A and B were treated with propofol at the dose rates of 6 and 10
mg/kg BW, respectively, while group C was given propofol and ketamine
hydrochloride in combination @ 4 mg/kg BW each and group D was treated with
thiopental sodium @ 20 mg/kg BW. Different reflexes were observed for evaluation
of anaesthetic efficacy. Groups C and D showed rapid
inductions, prolonged surgical stages and late recovery in most of the reflexes
and group C showed smooth recovery than D. Groups A and B showed smooth
induction, short surgical stages and rapid recovery. Group B also showed some
disturbances in respiratory and cardiac activity of the animals. It was
concluded that propofol in combination with ketamine hydrochloride is a safe
anaesthetic agent for canines as an alternative of thiopental sodium for
prolonged surgical procedures.