COMPARATIVE EFFICACY OF HYPERTONIC SALINE AND NORMAL SALINE SOLUTIONS IN
EXPERIMENTALLY INDUCED ENDOTOXIC SHOCK IN DOGS
M. ARIF ZAFAR, G. MUHAMMAD, M. HAMMAD HUSSAIN, T. AHMAD, A. YOUSAF AND
I.
SARFARAZ
Department of Clinical Medicine and Surgery,
University
of Agriculture,
Faisalabad,
Pakistan
Abstract
This study was contemplated to determine the comparative beneficial effects of
hypertonic saline solution and sterile saline solution in induced endotoxic
shock in dogs. For this purpose, 12 healthy Mongrel dogs were randomly divided
into two equal groups (A and B). All the animals were induced endotoxaemia by
slow intravenous administration of
Escherichia coli endotoxins 0111:B4. Group A was treated with normal saline
solution @ 90 ml/kg BW, while group B was given hypertonic saline solution @ 4
ml/kg BW, followed by normal saline solution @ 10 ml/kg BW. Different parameters
were observed for evaluation of these fluids including clinical and
haematological parameters, serum electrolytes, mean arterial pressure, and blood
gases at different time intervals up to 24 hours post treatments. After infusion
of respective fluids, all parameters returned to baseline values in both the
groups but group B showed better results than group A except bicarbonates, which
better recovered in group A. Thus, it was concluded that a small-volume of
hypertonic saline solution could be effectively used in reversing the
endotoxaemia. Moreover, it provides a rapid and inexpensive resuscitation from
endotoxic shock.