Department of Pathology,
1Department of Microbiology, University
of Agriculture,
Faisalabad,
Pakistan
Abstract
The effects on haematology of 48 rabbits (24 of each sex) were studied by
administering cypermethrin (CY) intraperitoneally. In each sex, animals were
divided into four equal groups A, B, C and D. The animals in groups B, C and D
received low (50 mg.kg-1 b. wt.), medium (100 mg.kg-1 b.
wt.) and high (150 mg.kg-1 b. wt.) CY doses, respectively in mustard
oil. Group A served as control and each animal received equivalent volume of
mustard oil. The animals received five CY treatments (d 1, 8, 15, 22 and 29).
Blood samples with anticoagulant from all animals were collected prior to
experiment (day 0) and after every treatment for haematological studies. The
total erythrocyte count (TEC), haemoglobin (Hb) concentration and packed cell
volume (PCV) were analyzed at each experimental period and erythrocyte indices
were calculated. During the experiment, significant increase in mean corpuscular
volume (MCV) and significant decrease in TEC, Hb concentration and mean
corpuscular Hb concentration (MCHC) were found in the male rabbits treated with
CY especially at higher doses, while the decrease in these parameters in the
female rabbits was non-significant at all dose levels and time periods. Thus, it
was concluded that macrocytic hypochromic anaemia was induced in the male
rabbits due to CY treatment, but not in the females at the dose levels
administered during the study.