Distribution of Lymphocytes in the Mucosa Associated
Lymphoid Tissues (MALT) of Naturally Occurring Infectious Bursal
Disease (IBD) in Chicken
M. M. Uddin*, M. Z. I. Khan1, K. N.
Islam, A. S. M. G. Kibria, G. N. Adhikary2, M. N. H.
Parvez3, J. Basu, M. B. Uddin4 and M. M.
Rahman5
Department of
Anatomy and Histology, Faculty of Veterinary Medicine, Chittagong
Veterinary and Animal Sciences University, Chittagong; 1Department
of Anatomy and Histology, Faculty of Veterinary Science, Bangladesh
Agricultural University, Mymensingh; 2Department
of Anatomy and Histology, Faculty of Veterinary and Animal Science,
Sylhet Agricultural University, Sylhet; 3Department of
Anatomy and Histology, Faculty of Veterinary and Animal Science,
Hajee Mohammad Danesh Science and Technology University, Dinajpur;
4Department of Medicine and Surgery, Faculty of
Veterinary Medicine, Chittagong Veterinary and Animal Sciences
University, Chittagong; 5Department of Pathology and
Parasitology, Faculty of Veterinary Medicine, Chittagong Veterinary
and Animal Sciences University, Chittagong, Bangladesh *Corresponding author:
mmu_cvasu@yahoo.com
Abstract
This study was aimed to investigate changes in
the number and distribution of lymphocytes in the mucosa associated lymphoid
tissues (MALT) of digestive tract (proventriculus, duodenum, jejunum, ileum,
cecum and cecal tonsils) and respiratory system (lungs) of chicken infected by
Infectious Bursal Disease Virus (IBDV). Samples were divided into two groups;
IBDV infected group (21, 24 and 30 days old) and control group (non infected
birds; 21 days old). Haematoxylin and eosin stained slides were prepared for
microscopic studies to observe the distribution and the number of lymphocytes in
the mucosa of the digestive tract and respiratory system. Lymphocytes were
significantly(P<0.05) lower in
proventriculus, duodenum, jejunum, ileum, cecum, cecal tonsils and lungs of IBDV
infectedchickens than the control.
Moreover, the reduction in lymphocytes number was maximum in duodenum and cecal
tonsils, while minimal in lungs. Depletion of lymphocyte was mainly in the
lamina propria and the core of the villi and depletion increased with the
advance of age of IBDV infected chicken. These results demonstrate that IBDV
destroys the lymphocytes of the MALT and suppresses the immunity.