Effects of Hypertonic Saline Solution on Clinical Parameters, Serum
Electrolytes and Plasma Volume in the Treatment of Haemorrhagic
Septicaemia in Buffaloes
M. Arif Zafar*, G. Muhammad, Zafar Iqbal1 and M. Riaz2
Department of Clinical Medicine and Surgery; 1Department
of Parasitology and 2Department of Livestock Management,
University
of
Agriculture,
38040,
Faisalabad,
Pakistan
*Corresponding Author:
drmarifzafar@hotmail.com
Abstract
This study was conducted to determine the efficacy of hypertonic saline solution
(HSS) along with antibiotic (ceftiofur HCl) and non-steroidal anti-inflammatory
drug (ketoprofen) in the treatment of haemorrhagic septicaemia in buffaloes.Forthis purpose, 50 buffaloes
suffering from haemorrhagic septicaemia were randomly divided in two equal
groups A and B. Group A served as control and was treated with ceftiofur HCl
(IM) and ketoprofen (IV) @ 6 and 2 mg/Kg BW, respectively, for five days.
Buffaloes of group B were administered with rapid intravenous infusion of
hypertonic saline solution (7.5% NaCl) @ 4 ml/Kg BW once in combination with
ceftiofur HCl and ketoprofen. Animals were monitored for 24 hours after
initiation of treatment. Clinical parameters, serum electrolytes, plasma volume
and survival index were recorded
at different intervals after treatment.Survival rate (80%) in group B was
significantly higher (P<0.05) than 48% in group A. The heart rate and
respiration rate recovered more effectively in the buffaloes administered with
treatment protocol B.Plasma volume
was 98% which was almost normal within 24 hours after the infusion of hypertonic
saline solution to the animals of group B.It was concluded from the study that hypertonic saline solution as an
adjunct to antibiotic and a non-steroidal anti-inflammatory drug more
efficiently improved respiration and heart rates and effectively restored plasma
volume in resuscitating the buffaloes from haemorrhagic septicaemia than the
conventional treatment.