This study was conducted to compared the serum biochemical parameters of the Rattus rattus as influenced by feeding two different rodenticides i.e., brodifacoum and food energy inhibitor (cellulose). The experiment was conducted on total 42 rats which were divided equally into 3 groups. One group was fed brodifacoum while the other was fed cellulose. The third group served as a control. Both the groups were fed with the calculated amount of brodifacoum and cellulose for 14 days. At the end of experiment, rats of all the three groups were killed and blood was collected to obtain serum. Significantly low feed intake was recorded in food energy inhibitor fed group. Serum was analyzed for glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), Triiodothyronine (T₃) and Thyroxine (T₄). It was observed that serum glucose and T₃ were significantly low (p<0.05) in brodifacom fed group while ALT and T₄ were significantly high (p<0.05) in brodifacom fed rats. The biochemical comparison of these rodenticides provides useful information regarding the controlling strategy of Rattus rattus.

Key words: Biochemistry, Brodifacom, Cellulose, Rattus rattus