A study was conducted to evaluate the hypoglycemic effect of Zingiber officinale (Ginger) aqueous extract at a dose of 500mg/kg body weight (BW) once a day for six weeks. The rats were made diabetic by intraperitoneal injection of alloxan (65mg/kg BW once) which induced diabetes in albino rats after 8 days.  Albino rats (n=24) each weighing 150-180g were divided in 3 equal groups. Group A served as control, group B was diabetic and was not given ginger whereas group C rats were diabetic and given ginger extract (500mg/kg BW). Serum of each rat was analyzed by enzymatic kits to estimate serum glucose on 1^st day (after making them diabetic), 21^st and 42^nd day. No significant changes were observed in control or diabetic (A & B) groups who were not fed ginger extract. The group C which was given ginger extract showed significant (P<0.05) reduction in serum glucose level after 21 and 42 days treatment. It may be concluded that ginger extract has hypoglycemic effect on diabetic rats.

Key words: Alloxan; Diabetic rats; Hypoglycemic; Zingiber Officinale