Toxicological Effects of Brodifacoum and Food Energy Inhibitor on
Some Physiological Parameters in House Rats (Rattus
rattus)
S. Naz*, S. A. Rana, M. Javed and Khalil-ul-Rehman1
Department of Zoology and Fisheries,
University
of
Agriculture,
Faisalabad;
1Department of Chemistry and Biochemistry,
University
of
Agriculture,
Faisalabad,
Pakistan
*Corresponding author: shabanapervez_2000@hotmail.com
Abstract
This study was conducted to investigate the effects of two different
rodenticides, i.e., brodifacoum (BRD) and food energy inhibitor (FEI) on some
physiological parameters in house rats (Rattus
rattus). A total of 42 rats were randomly divided into 3 equal groups. One
group served as a control while other two groups were fed BRD and FEI. Results
revealed that feed intake and body weights were significantly lower in FEI group
as compared with the control group. However, liver, heart and kidney weights
were significantly high in BRD group. Mean concentration of glucose and
triiodothyronine (T3) concentrations were significantly low in BRD
group, while alanine aminotransferase (ALT), aspartate aminotransferase (AST),
thyroxine (T4), LDH (lactate dehydrogenase) and CK-MB (creatinine-kinase)
concentrations were significantly high in the rats of BRD group. It was
concluded from this study that BRD has significant toxic effect on physiological
biochemistry of house rats as compared to FEI.
Key words: Brodifacoum,
Cellulose,
Food energy inhibitor,
House rats