Efficacy of Tylosine against Clinical Cryptosporidiosis in Goat Kids
Ethem Mutlu Temizel*, Sezgin Senturk, Onur Girisgin1,
Bayram Senlik1 and Gulsah Demir
Departmant of Internal Medicine, 1Departmant of
Parasitology, Faculty of Veterinary Medicine, University of Uludag,
Nilufer, Bursa, Turkey *Corresponding authors: ethem@uludag.edu.tr
Abstract
The aim of the present study was to evaluate tylosine efficacy administered by
intramuscular for treatment of cryptosporidiosis
in naturally infected goat kids. These
animals were randomly assigned to test group (n=10) and control (n=10) group
after routine clinical examination. All kids showed mild mental depression,
decrease in suckling reflex and diarrhea in different severity.Fecal samples were analyzed via virological, bacteriological and
coccidial examinations. The consistency of feces was assessed as pastose,
semiliquid, or liquid. The rates of infection of the samples were evaluated
semi-quantitatively. Tylosine was given by intramuscular route to test group - 2
at a dosage of 10 mg/kg of body weight, twice a day for 5 days. However,
isotonic saline solution (1.0 ml) was
used by intramuscular route to the control group, once a day for 5 days.
Hematological results of all the kids were within normal limits except for
hematocrit rates. 15 of the kids had mild high hematocrit rate as result of
dehydration. In parasitologic evaluation, totally 1051 and 1049
oocysts per gram
(OPG) were detected in all goat kids of study group and control group,
respectively. However, OPG was not detected in both of group after treatment. It
was suggests that tylosine applied animals has been shown more rapid recovery
than control group. Tylosine may be useful in order to reduce of treatment
period in the disease. In future, more detailed studies which evaluate the
effects of tylosine in goat kids with cryptosporidiosis are needed.