Effects of ceftiofur sodium liposomes on free radical formation in
mice
SR Liu, DH Zhou, SJ Yang and DZ Guo*
College
of Veterinary Medicine,
Huazhong Agricultural University,
Wuhan,
Hubei, China;
Department of Veterinary Medicine, Huazhong Agricultural University,
Luoshi Road, Wuhan, Hubei, 430070, China
*Corresponding author: srui.liu@gmail.com
Abstract
To
examine
the effects of ceftiofur sodium
liposomes on the free radical formation in liver of mice, 24 mice were assigned
randomly into three groups,
i.e., 1) ceftiofur sodium; 2) ceftiofur sodium liposomes and 3) physiological
saline. Treatments were applied via intraperitoneal injections for 7 days. At
the end of the treatment period, animals were euthanized and liver collected for
analysis of superoxide dismutase (SOD) activity and malondialdehyde (MDA)
contents
and
the ability of liver tissue to suppress hydroxyl radical
formation.
Ceftifur sodium liposomes-treated mice had higher activity of SOD
than ceftiofur sodium- and saline-treated mice; however,
MDA content and
the ability of liver tissue to suppress hydroxyl radical
formation did not reach statistical significance among groups.
It was concluded that ceftiofur sodium liposomes can
improve the SOD activity
compared to ceftiofur alone in mice.