Nephroblastoma with Pulmonary Metastasis in 33 Month Old Neutered
Piedmontese Male Cattle
Frine Eleonora Scaglione*, Parola Riccardo1, Botta
Michelangelo2, Abrate Mario3, Chiappino Laura,
Fiorito Eligio2, Valenza Federico and Bollo Enrico
Dipartimento di Patologia Animale, Università degli Studi di Torino,
Via L. da Vinci 44, 10095 Grugliasco (To), Italy; 1Practicing
Veterinarian, Frazione Valsuolo 56,14017 Valfenera (At), Italy; 2Servizio Veterinario
ASL CN1, Via
Lancimano 51, 12045 Fossano (Cn), Italy; 3Direttore
Struttura Complessa Anatomia Patologica Ospedale di Savigliano, Via
Ospedali 14, 12038 Savigliano (Cn), Italy
*Corresponding author:
frineeleonora.scaglione@unito.it
Abstract
A renal neoplasia was observed in a slaughtered 33 month old neutered
Piedmontese male cattle. The neoplastic tissue was characterized by lardaceous
features, and fibrotic tissue was evident with boundless interlacing, which
separated the lesion in distinct diffusely irregular lobules. The lungs showed
several macroscopical subpleuric nodules. Histological investigations showed
multiform and distinct features of renal tumour. Anaplastic and embryonal
aspects were represented by poorly differentiated or undifferentiated cells.
Rarely, neoplastic epithelial elements were organized in pseudo-tubular
formations. Immunohisto- chemical staining for detection of cytokeratins,
vimentin, actin, S100, desmin and
factor VIII was performed. Ultrastructural findings revealed two
different populations of epithelial cells. Histological, immunohistochemical and
ultrastructural findings in the lungs confirmed the diagnostic hypothesis of a
metastatic tumour from the kidney.
Key words: Bovine,
Histology,
Immunohistochemistry,
Nephroblastoma,
Transmission electron microscopy