A 9-year old, debilitated, female teddy goat, with a body weight of about 23 kg, was subjected to smear staining, histopathological examination and ELISA for the diagnosis of Johne’s disease (JD).  During postmortem, the intestine showed thick corrugated mucosa and the mesenteric lymph nodes were found enlarged and edematous. Acid fast bacilli of multibacillary form were detected in Ziehl-Neelsen stained smears prepared form the tissues which showed gross pathology. Histopathologically, the ileal mucosa was intensely infiltrated by mononuclear cells and one of the ileum-associated lymph node revealed a large granuloma in its para cortical region. Special staining of tissue sections demonstrated the occurrence of acid fast bacilli. The JD case was confirmed by using indirect ELISA. The present case was differed from the previously reported studies in two aspects viz 1) A confirmed case of multibacillary form of JD in a teddy goat 2) Unusual presence of a large granuloma in the lymph node.

Key words: Histopathology, Multibacillary Johne’s, disease, Teddy goat