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Verapamil Potentiate the Cardiodepressor Effect of Ethanol in Cat Papillary Muscle
José L. Martínez1*, Hiran Cabrera2 and Claudio Laurido3
1University of Santiago of Chile, Office of the Vice Rectory, Alameda 3363, Est. Central, Santiago, Chile; 2Central Laboratory of Pharmacology, Faculty of Medical Sciences Dr. Salvador Allende, University of Medical Sciences, Havana, Cuba; 3University of Santiago of Chile, Faculty of Chemistry and Biology, Santiago, Chile
*Corresponding author:


The possible additive effect of ethanol (EtOH) on verapamil on isolated papillary muscle of cats weighing 1200-1500 g kept in oxygenated Ringer Locke solution was studied. Papillary muscles were dissected from the right ventricle, mounted vertically in an acrylic support and stimulated electrically driven  at a constant rate by means of silver at 37oC (pH=7.4). We studied the effect on peak tension development (PTD) of verapamil (5.4 X 10-4 mM) and two EtOH concentrations (48.6 and 97.2 mM) in cat papillary muscle bathed in a normocalcic medium (2.2 mM) of Ringer-Locke solution.  EtOH in both concentration potentiated the decrease of PTD (inotropic effect), (-53.31±2.07% and -60.00±3.50%, respectively) compared to verapamil previously incubated in bath (-38.1±2.26%). It was concluded that verapamil induces a decrease in myocardial contraction by a posterior consumption of sufficient EtOH enough to put the patient in the risk of a lamentable induction of cardiac failure.

Key words: Cat, Ethanol, Papillary muscle, Verapamil


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)