Effectiveness of Xiang-Qi-Tang
against Avian Pathogenic Escherichia coli
Chang-Liang He*, Ben-Dong Fu1,
Peng-Fei Yi1, Xu-Bin Wei1, Zhong-Qiong Yin,
Cheng Lv, Wei Zhang, Xi-Mei Han and Xing-Li Cun
Department of
Pharmacy, College of Veterinary Medicine, Sichuan Agricultural
University, Xinkang Road 46, Ya’an, Sichuan, 625014, PR China;
1Department of Clinical Veterinary Medicine, College of Animal
Science and Veterinary Medicine, Jilin University, Xi’an Road 5333,
Changchun, Jilin 130062, PR China *Corresponding author: lorri190@126.com
Abstract
Xiang-Qi-Tang (XQT) is a Chinese medicine
containing Rhizoma Cyperi (40 g),
Andrographis paniculata (30 g)and Astragalus membranaceus (30 g). The purpose of this
study is to investigate the therapeutic effects of XQT
on Avian Pathogenic Escherichia coli
(APEC)-infected chickens. The
chickens were pretreated with XQT 12 h before being inoculated
with 108 colony forming unit (CFU) of APEC by subcutaneous
injection, and then the mortality and the indexes of health status of chicken in
each group were detected. The results showed that high dosage and middle dosage
of XQT could significantly decrease the
mortality of the chickens challenged with APEC. We further found
that XQT improved the infected chickens’
health status through improving the water consumption, feed intake, bodyweight gain, routine blood parameters and decreasing the incidences
of pericarditis and perihepatitis. The results of present study suggest that XQT
can effectively treat chicken colibacillosis as a potential agent.
Key words:
Chicken colibacillosis, Escherichia coli, Herbal medicine