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Resveratrol Reduces Oxidative Stress and Improves Arsenic Efflux in Rats Exposed To Arsenic Trioxide
Weiqian Zhang§,1, Yan Liu§,2, Ming Ge§,1, Chunyu Yao3, Jiangdong Xue3 and Zhigang Zhang*
1College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030; 2School of Life Sciences, Inner Mongolia University for Nationalities, Tongliao 028000;3College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao 028000, China
*Corresponding author:


The effects of resveratrol on arsenic trioxide-induced oxidative stress and arsenic efflux in spleen were determined in Wistar rats exposed to arsenic trioxide (As2O3). Wistar rats were segregated into four groups: control (0.9% normal saline), As2O3-treated (2 mg/kg for 7 days, i.p.), resveratrol+As2O3-treated, resveratrol-treated (5 mg/kg for 7 days, i.p.). Spleen was analyzed for lipid peroxidation, antioxidant enzyme activities, glutathione redox system and arsenic accumulation. Arsenic treatment showed significant increases in the malondialdehyde, reactive oxygen species and arsenic accumulation in spleen. Furthermore, arsenic treatment decreased significantly activity of superoxide dismutase and total glutathione/ oxidized glutathione ratio. However, treatment with resveratrol to arsenic-treated rats reduced oxidative stress and improved arsenic efflux. These findings may provide the potential strategy for arsenic-induced spleen toxicity and As2O3 as a single agent causing toxic effects.

Key words: Arsenic efflux, Arsenic trioxide, Oxidative stress, Resveratrol


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)