Estrogen Receptors Α and Β in a Pure Uterine Lipoma in a Dog
Han Jun Kim, Hye-Rim Lee, Ji-Han Kim1
and Sun Hee Do*
Departmentof Clinical Pathology, Collegeof Veterinary Medicine
and Veterinary ScienceResearch Institute, Konkuk University, Seoul 143-701,
Republic of Korea; 1 Love My PetAnimal Hospital, Seoul 122-010, Republicof Korea.
*Corresponding author:
shdo@konkuk.ac.kr
Abstract
A 7-year-old female Yorkshire terrier dog
presented with anorexia and fever due to pyometra; ovariohysterectomy was
therefore performed. Histopathological examination showed multiple cysts of
variable sizes with hyperplasticity of luteal cells, and the patient was
diagnosed with cystic ovarian disease. An abnormal growth and infiltration of
adipocytes in the uterus, especially at the border between the endometrium and
myometrium, was accidentally identified. Based on the clinical features and
histopathological findings, a diagnosis of pure uterine lipoma along with
ovarian cystic disease was made. Further immunohistochemical study revealed that
the lipomatous tissue was positive for the protein S-100, vimentin, and desmin,
as well as estrogen receptors alpha and beta, which is in contrast to humans.
Our results suggest a possible role of estrogen receptor signaling in abnormal
lipomatous tissue changes in the canine female genital tract. We present here
the first case of pure uterine lipoma in a dog and describe its characteristics.
Key words:
Adipocyte,
Canine,
ER-α,
ER-β, Pure uterine lipoma