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Hsp-90 Inhibitor Geldanamycin Attenuates Liver Oxidative Stress and Toxicity in Thiram-Induced Tibial Dyschondroplasia
Muhammad Shahzad1, 2, Jingying Liu1, Jianfeng Gao1, Zhi Wang1, Ding Zhang1, Fazul Nabi1 and Jiakui Li1*
1College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China; 2University College of Veterinary & Animal Sciences, The Islamia University of Bahawalpur 63100, Pakistan
*Corresponding author:


An experiment was conducted to study the effects of hsp90 inhibitor geldanamycin (17-DMAG) on liver functioning and its antioxidant ability in thiram-induced tibial dyschondroplasia. One hundred and twenty commercial chicken broilers were allocated into three groups: 1) control, 2) thiram-induced and 3) 17-DMAG treated. Serum samples were collected on day 11 and 14 post-hatch to determine the liver ALT, AST and ALP activity. The liver samples were collected at the end of trial to determine the activity of SOD (superoxide dismutase), GSH-Px (glutathione peroxidase) and MDA (malondialdehyde) contents. The results depicted that thiram increased the level of serum ALT, AST and liver MDA contents while decreased the serum ALP and liver antioxidant enzymes (SOD, GSH-Px); however, by administering 17-DMAG, these values were observed close to normal range as compared to control group. In conclusion, the oxidative imbalance and damage to liver caused by thiram can be restored by using 17-DMAG.

Key words: 17-DMAG, Biochemical changes, Thiram, Tibial dyschondroplasia


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)