1College
of Veterinary Medicine, Jilin University, Changchun 130062, People's
Republic of China; 2College of Animal Science and
Veterinary Medicine, Heilongjiang Bayi Agricultural University,
Daqing 163319, People's Republic of China;
*Corresponding author: xbli@jlu.edu.com (XB Li); lixinwei100@126.com (XW Li)
Abstract
Nonalcoholic fatty liver disease (NAFLD) is a
common liver disease that
manifests as a wide range ofpathological conditionsranging from fat accumulation to inflammation, fibrosis
and finally cirrhosis. Recently, it suggested that hypothyroidism is closely associated with NAFLD. In
addition, 11.7% of hepatocellular carcinoma (HCC) patients were shown to have hypothyroidism.
In this study,
Wistar rats were fed different high-fat diets (with or without propylthiouracil)
and allowed to develop NAFLD. At the end of the experiments, the serum and liver
were collected for the analysis of lipid and cholesterol metabolism parameters.
Our results showed that the hypothyroid rats had a fleshless body, significantly
higherconcentrations of total cholesterol
(TC) and low-density lipoprotein cholesterol (LDL-c) in the serum and an
increased serum alanine transaminase (ALT) level. In addition, the concentration
of serum triglycerides and the expression of ApoB100, MTP, SREBP-2 and ABCA1 in
the hypothyroid rats showed fluctuating patterns similar to that of liver
triglycerides. This finding suggested that propylthiouracil-induced
hypothyroidism plays an important role in progressive NAFLD.