Immunostimulatory Properties of
Spirulina platensis against Rabbit Hemorrhagic Disease Virus
Elena Kistanova1*, Mihail Chervenkov1, Kiril Shumkov1, Rayko
Peshev2, Krasimira Todorova1, Soren
Hayrabedyan1, Desislava Abadjieva1, Almantas
Shimkus3 and Aldone Shimkiene3
1Institute
of biology and immunology of reproduction, BAS, 73 Tzarigradsko
shose, 1113 Sofia, Bulgaria; 2National
diagnostic and research veterinary medicine institute, Bul. Pencho
Slaveikov 15a, 1606 Sofia,
Bulgaria; 3University of health sciences, A.
Mickevičiaus g. 9, 44307
Kaunas, Lithuania *Corresponding author:
kistanova@gmail.com
Abstract
Given thehigh risk, hemorrhagic
disease virus (RHDV)leading to 100%
mortality of the infected
rabbits, special attention has to be paid to form anadequate andtimelyimmunity aftervaccination.
The present investigation aimed to analyze the ability of the
Spirulina (S.)
platensis, enriched of phycocyanin, carotenoids, iron and selenium throughmodified technology of growth, to boost the immunity of the vaccinated
rabbits against RHDV.The experimental
white rabbits were fed 1g dry biomass S.
platensis per head daily one month before and three months after vaccination
with PESTORIN (Bioveta, Czech). The antibody titers against RHDV were determined
at days 15, 30, 60 and 90 post-vaccination. Faster and higher production of the
specific antibodies against RHDV was observed in animals treated with whole
biomass of algae. The S. platensis,
enriched with bioactive components, could be beneficial for supporting the
immunization against RHDV.