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Immunostimulatory Properties of Spirulina platensis against Rabbit Hemorrhagic Disease Virus
Elena Kistanova1*, Mihail Chervenkov1, Kiril Shumkov1, Rayko Peshev2, Krasimira Todorova1, Soren Hayrabedyan1, Desislava Abadjieva1, Almantas Shimkus3 and Aldone Shimkiene3
1Institute of biology and immunology of reproduction, BAS, 73 Tzarigradsko shose, 1113 Sofia, Bulgaria; 2National diagnostic and research veterinary medicine institute, Bul. Pencho Slaveikov 15a, 1606 Sofia, Bulgaria; 3University of health sciences, A. Mickevičiaus g. 9, 44307 Kaunas, Lithuania
*Corresponding author:


Given the high risk, hemorrhagic disease virus (RHDV) leading to 100% mortality of the infected rabbits, special attention has to be paid to form an adequate and timely immunity after vaccination. The present investigation aimed to analyze the ability of the Spirulina (S.) platensis, enriched of phycocyanin, carotenoids, iron and selenium through modified technology of growth, to boost the immunity of the vaccinated rabbits against RHDV.  The experimental white rabbits were fed 1g dry biomass S. platensis per head daily one month before and three months after vaccination with PESTORIN (Bioveta, Czech). The antibody titers against RHDV were determined at days 15, 30, 60 and 90 post-vaccination. Faster and higher production of the specific antibodies against RHDV was observed in animals treated with whole biomass of algae. The S. platensis, enriched with bioactive components, could be beneficial for supporting the immunization against RHDV.

Key words: Antibody titer, Immunomostimulation, Rabbit hemorrhagic disease virus (RHDV), Spirulina platensis, Vaccination


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)