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Metastatic Kidney Carcinoma Causing Paralysis of Pelvic Limbs in a Dog
SG Calazans1*, CEF Alves2, NM Zanetti3, VA Conforti1, J Santilli1, DS Anjos1 and GM Magalhães1
1Animal Science Graduate Program, University of Franca – UNIFRAN: Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, São Paulo, 14404-600, Brazil; 2Veterinary Medicine Graduate Program, São Paulo State University – UNESP: Av. Prof. Montenegro, s/n, Distrito Rubião, Botucatu, São Paulo, 18618-970, Brazil;  3Advanced Veterinary Medical Center – CAVET: Rua Guimarães Passos, 592, Vila Seixas, Ribeirão Preto, São Paulo, 14020-070, Brazil; *Corresponding author:


A 12-year-old male Maltese dog was presented with a history of shivering episodes. Radiographs revealed a mass in the left kidney that was histopathologically classified as a renal cell carcinoma. After nephrectomy, pelvic limbs became paralyzed. Spinal cord and lung metastases were detected via histopathological examination and confirmed by immunohistochemistry. Both pan-cytoketatin and Ki67 assays tested positive in the kidney, lung, and spinal cord. Interestingly, COX-2 had mild immunoreactivity in the kidney, but its labeling was intense in the spinal cord and lung. Though seemingly rare, the spinal cord may possibly be a focus point for metastasis of renal cell carcinomas. Because symptoms can easily be misunderstood, late diagnoses would not be uncommon and may hinder clinical management of the disease.

Key words: Canine, Metastasis, Pan-cytoketatin, Renal neoplasm, Spinal cord


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)