Serum Potassium-Lowering Effects of Insulin Plus
Dextrose and Adrenalin Treatment that Enhance Intracellular
Potassium Transitions in Hyperkalemic Diarrheic Calves
N Altuğ1, *, N
Yüksek2, C Özkan2, Y Başbuğan2, İ
Keleş3, ZT Ağaoğlu4, A Kaya2 and Y
Akgül2
1Department of Internal
Diseases, Faculty of Veterinary Medicine, University of Namık Kemal,
59030, Tekirdağ, TURKEY; 2Department of Internal
Diseases, Faculty of Veterinary Medicine, University of Yuzuncu Yil,
65080, Van, Turkey; 3Department of Internal Diseases,
Faculty of Veterinary Medicine, University of Erciyes, 38090, Kayseri, Turkey; 4Department of Internal
Diseases, Faculty of Veterinary Medicine, University of Cumhuriyet,
58140, Sivas, Turkey;
*Corresponding author:nurialtug@gmail.com
Abstract
The study examined the
serum potassium-lowering effects of different treatment options for hyperkalemia
in diarrheic calves (n=18). Calves were allocated into three treatment groups. All
groupsreceived isotonic sodium
bicarbonate solution for a period of90 minutes.
The animals in group 1 received no further treatment,
those in group 2 received a further dose of 50% dextrose and insulin,
and those in group 3 received a further dose of
adrenaline. Highserum Klevelsin all groups significantlydecreased after treatment (AT) than before treatment
(BT).Serumpotassium levels AT
in groups 2 and 3were found to besignificantlylower than those ingroup 1. Increasein pH, bicarbonate and total carbon dioxide values were
observed ATin all groups. However,
bicarbonate and total carbon dioxide
levels in the ATwere not
statistically significantly different from those in the adrenaline
group compared with the groups 1. These parameters were
significantly lowerin the group 2.
Moreover, the concentration of glucose in the groups 2 in contrast to the adrenalin group was higher than that in both the BT
and group 1 AT. The insulin + dextrose
combination and adrenaline applications in hyperkalemic calves had similar
effects. However, the administration
of adrenaline had a lower negative effect on metabolic acidosis
treatment.