previous page   Pak Vet J, 2016, 36(3): 338-343   next page
Experimental Superinfection of Bovine Viral Diarrhea Virus in Persistently Infected Korean Native Calves
Ha-Young Kim1,§, Eun-Jung Bak2,§, Jae-Jo Kim1 and Gye-Hyeong Woo3,*
1Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, Gimcheon, Gyeongbuk 39660; 2Oral Cancer Research Institute, Yonsei University, Seoul 03722; 3Laboratory of Histopathology, Department of Clinical Laboratory Science, Semyung University, Jecheon, Chungbuk 27136, Republic of Korea
*Corresponding author:


Two male calves infected with non-cytopathic (ncp) bovine viral diarrhea virus (BVDV) BVDV-1c in survey study were donated and superinfected experimentally with cytopathic (cp) BVDV-1a via the intranasal (calf 1) or intravenous (calf 2) route to perform clinical, pathological, and serological evaluation using different inoculation routes. Both calves were moribund and euthanized at post-inoculation days (PID) 30 and 38 without diarrhea, respectively. Gross and histopathological lesions were not prominent in calf 1, and the cp BVDV could not be isolated from samples from this calf. More severe and characteristic upper gastrointestinal lesions, including deep ulceration and lymphocytic inflammation in the digestive system, were noted in calf 2 than in calf 1. Moreover, the cp BVDV-1 was isolated from various organs or tissues in calf 2. These results indicate that the inoculation route of cp BVDV-1 could be an important factor in the induction of mucosal disease in PI calves.

Key words: BVDV, Cattle, Inoculation route, Mucosal disease, Persistent infection


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)