The Pulmonate Limpet
Siphonaria lessoni: Pharmacological Study of Norsiphonarienone, a
Polipropionate
José L Martinez1*,
Juana Rovirosa2, Claudio Laurido3†, Aurelio San Martin2, Raul Vinet4 and Luisauris
Jaimes3
1Vicerrectory
of Research, Development and Innovation, University of Santiago of
Chile; 2Faculty of Sciences, University of Chile; 3Faculty
of Chemistry and Biology, University of Santiago of Chile; 4Faculty
of Pharmacy, University of Valparaíso & CREAS-Valparaíso, Chile;
†Died on October 09, 2017 *Corresponding author: joseluis.martinez@usach.cl
Abstract
We presented a marine natural product,
norsiphonarienone, isolated from
Siphonaria lessoni, a pulmonate limpet of Central Chile. The
norsiphonarienone was pharmacologically studied in rat thoracic aorta with
endothelium previously contracted with phenylephrine. This technique has been
widely used to describe pharmacological characterization and seek for mechanisms
of action of natural products and other physiological phenomena. The main
characteristics described are pD2 (-log EC50) and maximum
effect or maximal contraction (Emax). The results show that
norsiphonarienone induced a significant difference in the maximal contraction
and also in the pD2 (-log EC50).
Key words:
Norsiphonarienone,
Pharmacological study,
Rat thoracic aorta,
Siphonaria lessoni