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Clinical and Economic Impacts of a Commercial Vaccine Containing Recombinant Antigen against Atrophic Rhinitis in Field Conditions
Myung Hyee Kim1,2, Sung J. Yoo1, Taeyong Kwon1, Sang H Jae1, Dong-Uk Lee1, Jeongjae Byun1, Jeongyeon Shin1, Sang won Seo1,2 and Young S Lyoo1,*
1College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, South Korea; 2Hipra Korea, Inc., 262 Hwangsaeul-ro, Bundang-gu, Seongam-si, Gyeonggi-do 13557, South Korea
*Corresponding author:


Atrophic rhinitis (AR) is an important disease continuously causing economic losses to pig industry. Due to the detrimental effects on growth performance, antibiotics have been widely used to treat the bacterial diseases in the field. As the concerns about bacterial resistance to antibiotics increase, there is a growing need for the evaluation of AR vaccine that can reflect actual cost and benefits. However, until now, only limited research data have been available. Therefore, in this study, the systemic analyses of clinical and economic benefits by AR vaccination under field conditions were conducted. The trials were performed using a bivalent commercial vaccine containing Bordetella bronchiseptica bacterin and recombinant Type D Pasteurella multocida toxin in three different commercial pig farms endemic for AR. Significant higher levels of colostral antibodies and those passive transfer were detected from vaccinated sows to their offspring compared to non-vaccinated groups. As predicted on serological data, notably better clinical protection from the deleterious effects of AR was identified in piglets born to the vaccinated sows based on body weight, rearing period, and gross nasal scores. Moreover, vaccination on sows delivered a return on investment at least ten times the cost of vaccination. Collectively, these favorable clinical and economic effects in the commercial farms sufficiently support the necessity and significance of AR vaccination on sows.

To Cite This Article: Kim MH, Yoo SJ, Kwon T, Jae SH, Lee DU, Byun J, Shin J, Seo SW and Lyoo YS, 2018. Clinical and economic impacts of a commercial vaccine containing recombinant antigen against atrophic rhinitis in field conditions. Pak Vet J, 38(4): 394-398.


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)