Effect of Herbal Mixture as Angiotensin Converting Enzyme
Inhibitor in Angiotensin-II Dependent Hypertension
Farieha1, Nazish Jahan1,
Khalil-ur-Rahman2 and Shaukat Ali1
1Department
of Chemistry; 2Department of Biochemistry; University of
Agriculture, Faisalabad 38040, Pakistan *Corresponding author:
nazishjahanuaf@yahoo.com
Abstract
The effect of herbal mixture of
Curcuma longa (CL) and
Rauvolfia serpentina (RS) as green ACE
inhibitors in Angiotensin-II dependent hypertension was evaluated by measuring
the changes in ACE level in blood serum of hypertensive dogs.
2K1C Renovascular Hypertension Model (RVHM) was used to introduce
hypertension in dogs. Substantial Hypertension was induced after seven days of
renal artery ligation (RAL) with significant increase in the level of ACE in
blood serum of spontaneously hypertensive dogs (SHD). Experimental dogs were
divided into four groups among them RVH hypertension was induced in the dogs of
three groups and fourth group was the normotensive dogs. Hypertensive dogs of
one group left untreated while the other two groups treated with herbal mixture
and standard drug (Captopril) respectively. The herbal mixture showed
significant decrease in Systolic blood pressure (SBP) pressure, diastolic blood
pressure (DBP), Pulse rate (PR), and serum ACE level of SHD as compared to
Captopril. SBP, DBP and PR were also correlated with hematological parameters.
Daily oral administration of herbal mixture resulted in a time-dependent blood
pressure and ACE level reduction in SHD, with management of hypertension after
nine days treatment. White blood cells (WBC), Lymphocyte (LYM), Mid-sized cells
(MID), Granulocyte (GRA), platelet count (PLT), mean corpuscular volume (MPV),
platelet distribution width (PDW) and platelet crit (PCT) showed highly
significant (P<0.01) positive correlation with SBP, DBP and PR while (red blood
cells) RBC showed significant (P<0.05) positive correlation only with SBP and
PR. This study demonstrated that the combination of
CL and
RS effectively reduced blood pressure
and heart rate of SHD and this antihypertensive effect is probably due to the
reduction of ACE level in blood serum.
To Cite This Article:
Farieha, Jahan N, Rehman KU and Ali S, 2019.
Effect of herbal mixture as Angiotensin converting enzyme inhibitor in
Angiotensin-II dependent hypertension. Pak Vet J, 39(1): 25-30.http://dx.doi.org/10.29261/pakvetj/2018.103