High immune response (HIR) cows have balanced and roborant host defences and lower disease, and selecting young sires is more essential than selecting cows. Foot and mouth disease (FMD) is a communicable disease in cattle, but there is no convenient method for selecting HIR young sires to FMD. In this study, 39 young Holstein sires were vaccinated by a trivalent FMD serotypes (A, O and Asia I) vaccine. Blood samples were obtained from Jugular vein before vaccination and at day 51 after primary vaccination (APV), and antibody levels of the three FMD serotypes, T-cell subsets and routine hematological parameters were detected. HIR and low immune response Holstein young sires were classed by the antibody levels of the three FMD serotypes at day 51 APV. The relation of the antibody levels with the T-cell subsets and routine hematological parameters were analyzed. The results showed that the immune response capability were related to the amounts of CD3⁺CD4⁺ and CD3⁺CD8⁺ lymphocytes, and the CD4/CD8 ratio was correlated to the antibody titers after vaccination. In conclusion, level of platelet and mid cell count before vaccination, and CD4/CD8 ratio and level of platelet after vaccination may be used to select the HIR young sires.

To Cite This Article: Yang L, He K, Li J, Ma Y, Li R, Hou M, Gao Y and Zhong J, 2019. Correlation of antibody levels with peripheral lymphocyte subsets and routine hematological parameters after vaccination with fmd vaccine in young sires. Pak Vet J, 39(2): 251-255. http://dx.doi.org/10.29261/pakvetj/2019.045