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Effects of Indomethacin on the Norepinephrine-Induced Contraction in Vascular Smooth Muscle during Different Stages of the Estrous Cycle
José L Martinez1, María E. Bruzzone2, Bernardo Morales3, Javier Palacios4, Luisauris Jaimes3, Marcela Knox5, Raúl Vinet5,6 and Claudio Laurido3*
1Vicerrectoria de Investigación, Desarrollo e Innovación, Universidad de Santiago de Chile, Santiago, Chile
2Facultad de Ciencias Biológicas, Universidad Andrés Bello, Santiago, Chile; 3Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile; 4Facultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique, Chile; 5Facultad de Farmacia, Universidad de Valparaíso, Valparaíso, Chile; 6Centro Regional de Estudios en Alimentos Saludables (CREAS)
*Corresponding author:
"Dedicated to Dr. Berta Zamorano"


Previous studies have shown that vascular reactivity evaluated in female rat aorta to norepinephrine did not present the same response at all periods of their estrous cycle. During proestrus, the contractile response shows lower values. It was also reported that vascular reactivity had a close relationship with prostaglandins activity. In this study, we studied the response to norepinephrine in rat aorta rings treated with indomethacin. Indomethacin is a well-known inhibitor of prostaglandin synthesis. At low concentrations, the effect of indomethacin was not significant, and vascular reactivity response to norepinephrine was similar to those aortic rings from the control rats (without indomethacin). However, at high concentrations of norepinephrine, a marked difference was observed. The inhibitory action of indomethacin on the synthesis of prostaglandins was effectively reflected in a lower release of prostaglandins. In this way, our results confirm previous findings and indicate that indomethacin increases the constrictor response to norepinephrine, avoiding the vasodilatory effect of prostaglandins.

To Cite This Article: Martinez JL, Bruzzone ME, Morales B, Palacios J, Jaimes L, Knox M, Vinet R and Laurido C, 2019. Effects of indomethacin on the norepinephrine-induced contraction in vascular smooth muscle during different stages of the estrous cycle. Pak Vet J, 39(3): 443-446.


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)