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Using Roquefortine C as a Biomarker in Hay for Penitrem A Intoxication in a Beef Herd

F Bonelli1,2, V Meucci1, L Turini1,2* and M Sgorbini1,2

1Department of Veterinary Sciences, University of Pisa, Viale delle Piagge 2, 56124, Pisa, Italy
2Centro di Ricerche Agro-Ambientali “E. Avanzi”, University of Pisa, via Vecchia di Marina 6, 56122, San Piero a Grado (PI), Italy; *Corresponding author:


Fifteen grazing beef cattle and calves presented a history of neurological signs like ataxia, intentional head tremors, muscle twitching. Nervous ketosis, nervous BVD, BHV-1,5, tremorgenic intoxication from hay, and Listeriosis were considered as differential diagnosis. Blood samples were collected. Inspection of hay bales showed large white dusty and moldy areas. Samples were taken and analyzed. Altered hay was immediately removed in all animals’ stock. No alterations were found in blood tests. Food analysis showed high concentrations of Roquefortine C (RC) (345 μg/kg DM). Tremorgenic syndrome has been reported in Penitrem A (PA) intoxication, but PA is difficult to isolate in laboratory conditions. Both RC and PA are produced by Penicillum spp. RC has been associated with PA in tremorgenic toxicosis in dogs and it might be considered a valuable diagnostic marker for PA intoxication. The neurological signs were due to tremorgenic intoxication after feeding of spoiled forage contaminated with mycotoxins.

To Cite This Article: Bonelli F, Meucci V, Turini L and Sgorbini M, 2020. Using roquefortine c as a biomarker in hay for penitrem a intoxication in a beef herd. Pak Vet J, 40(1): 136-138.


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)