Ever since the reduction of antimicrobial growth promoters in animal feed, infectious diseases have re-emerged in certain parts of the world, necrotic enteritis (NE) for one. The current study determines the protective efficacy of egg yolk antibodies (EYAs) in experimentally infected broiler chicken. Eighty (80), day-old broiler chickens were procured and divided into four groups (G₁-G₄). Group G₁ served as a negative control, while G₂ served as positive control viz infected with C. perfringens type A (1 x 10⁸ cfu/ml) from days 17-19 of the experiment. Groups G₃ and G₄ immunized passively with anti-clostridial IgY @ 1 ml per bird between days 21-24 via oral route, while 22^nd and 24^th days via I/M route, respectively. Two killings were performed (days 26^th and 35^th) and the birds were observed for growth performance, hematology and serum biochemistry. The study results showed a statistically significant decrease in growth, hematology and serum protein values, while elevation in serum enzyme values of the birds in group G₂ when compared to group G₁. The groups G₃ and G₄ (passively immunized) showed the values less affected and close to the physiological ranges. Hence it was concluded that anti-clostridial EYAs (IgY) has ameliorative effects against experimental clostridial infection in broiler chicken.