Poultry industry is growing at large scale being good source of animal origin protein for the humans. To have optimum output in terms of meat and eggs many practices are being applied to the commercial flocks. Different types of the growth promoters including phytochemicals, amino acids, organic acids and antibiotics at sub-therapeutic dosages are used. This use of antibiotics as growth promoter led to the antimicrobial resistance which is big challenge for the poultry industry in terms of infection control and residues in the meat. It also has concerns in terms of One Health Triad. Because this sub-therapeutic use of antibiotics leads to the emergence of superbugs for the birds as well for humans. There is a dire need to find out some alternative approaches those not only improve the growth performance as well as boost the immune system of the birds that prevents the outbreaks of the infections. Many prebiotics and probiotics are being identified those can be used in poultry to improve the efficiency of flocks, quality of meat and also enhance the profit margins of the framers. Probiotics have many advantages over the other growth promoters as per the published literature. So, in this article a comprehensive review of the probiotics, types, how they affect the bird’s physiology and immune system that can make them a safer choice, has been done so that they can pave the way about future of the probiotics for the poultry scientists and farmers.