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Effects of Gibberellic Acid on Thioacetamide-Induced Acute Liver Toxicity in Sprague-Dawley Rats
Haytham Mohamedelfatih Mohamed Makki1#, Gareeballah Osman Adam1,2#, Dong Kwon Yang1, Tsendsuren Tungalag1, Sei-Jin Lee3, Jin-Shang Kim1, Shang-Jin Kim1* and Hyung-Sub Kang1*

1Department of Veterinary Pharmacology & Toxicology, College of Veterinary Medicine, Jeonbuk National University, Specialized Campus, 79 Gobong-ro, Iksan-si, Jeollabuk-do 54596 Republic of Korea; 2Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, Sudan University of Science and Technology, P.O. Box No. 204, Hilat Kuku, Khartoum, Sudan; 3Korea Basic Science Institute Jeonju Center, Jeonju 54896, Republic of Korea
#Both authors contributed equally to this work as co-first authors.
*Corresponding author: (SJ Kim), (HS Kang).


Gibberellic acid (GBA) is a natural plant growth hormone, controlling many developmental processes. In order to explore the protective effects of GBA against Thioacetamide (TAA)-induced acute liver toxicity, thirty male Sprague-Dawley (SD) rats were randomly allocated into six groups (5 rats/group); Normal control (NC): received distilled water (DW) per os (p.o.), GBA only: received (20 mg/kg, p.o.) of GBA, TAA: received DW and TAA (350 mg/kg, i.p.), GBA 5: received GBA (5 mg/kg, p.o.) and TAA (350 mg/kg, i.p.), GBA 10: received GBA (10 mg/kg, p.o.) and TAA (350 mg/kg, i.p.), and GBA 20: received GBA (20 mg/kg, p.o.) and TAA (350 mg/kg, i.p.). Blood and plasma were collected for biochemical analysis while liver tissues were harvested and preserved for histological analysis. The results confirmed the TAA-induced acute liver toxicity by the significantly increased liver enzymes, hypoglycemia, hypoxia, polycythemia, and metabolic acidosis as compared with NC. However, pretreatment of TAA-intoxicated rats with GBA indicated the hepatoprotective effects by reducing liver enzyme levels significantly and alleviating hepatic lesions in a dose-dependent manner.

To Cite This Article: Makki HMM, Adam GO, Yang DK, Tungalag T, Lee SJ, Kim JS, Kim SJ, Kang HS 2022. Effects of gibberellic acid on thioacetamide-induced acute liver toxicity in sprague-dawley rats. Pak Vet J, 42(4): 481-486.   


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)