Seafood is an essential part of nutrient acquisition and is considered a staple food in areas located nearby water bodies.  The potential pathogens associated with seafood consumption are often neglected to make foodborne zoonosis more likely to occur. Anisakiasis resulting from infected nematodes Anisakis has worldwide distribution including developing continents like Asia (China, Japan, Korea and Bangladesh) and some developed areas like the Netherlands and the United States. Despite a global burden of morbidities and fatalities, Anisakiasis remains a neglected zoonotic disease. The intensity and distribution of disease rise owing to the consumption of different kinds of raw or improperly cooked seafood like sushi etc. There is no proper treatment for Anisakiasis owing to the delays in reaching out for medical opinions. Keeping in view the gaps in Anisakiasis research and surveillance, we should improve the treatment with medicine, surgery, and essential oil and curtail the transmission of diseases from parasites to humans. There are gaps in the existing information on the epidemiological significance of the so far known species of Anisakis, both in their natural and accidental host-like human population worldwide. This review signifies the importance of awareness, knowledge of Anisakiasis among humans and animals from a global viewpoint. A holistic approach by thorough assessment of the rapidly spreading disease Anisakiasis in natural and accidental hosts as well as in marine ecosystems is required to prevent morbidities and mortalities in humans..