Poultry is the second largest industry among the world`s various industries. This industry is highly affected by “salmonellosis” causing clinical signs like diarrhea, inappetence, vomiting, and sometimes death. This disease is becoming deadly due to antibiotic resistance which has been curtained as a worldwide security risk. Probiotics are microbes that can help chickens in the fight against pathogens in their gastrointestinal tracts. The most commonly and effectively used probiotics are those derived from Bacillus species. Probiotics establish cross-feeding among various bacterial strains in the gut environment, lowering blood cholesterol levels. In current years, there has been an increase in the occurrence of infections due to some strains of Salmonella which are resistant to multiple antibiotics. The use of antibiotics in poultry causes an enormous impact on the selection of antibiotics. A significant fraction of the world's consumption of antibiotics is being used in poultry. There is a knowledge vacuum regarding the establishment of bacterial resistance from poultry in resource-constrained contexts. The probiotics market share is rapidly growing. Asia is going to make the largest part of it as the growth is maximum in India, Pakistan, China and Japan. The aim of this review is to emphasize and overview the use of Bacillus probiotics instead of antibiotics to treat resistant genes of Salmonella.