Listeriosis is an infectious and fatal disease of domestic mammals and humans caused by Listeria monocytogenes (L. monocytogenes). This study discusses the prevalence, pathology, microbiology, and molecular characterization of reported encephalitic listeriosis cases in caprine and ovine species in the north of Oman between 2017 and 2019. Thirty suspected small ruminants (goats=20 and sheep=10) were reported from eight outbreaks in northern Oman during the 3 years. The overall morbidity, mortality, and case fatality in goats were 5.8, 5.5 and 95%, respectively, while in sheep, were 8.4, 4.2 and 50%, respectively. Animals under 12 months of age had a case fatality rate of 100% compared to 50% in animals older ‎than one year. ‎The clinical signs in all reported cases were fever, anorexia, deviated ‎neck, and circling. Necropsied animals showed no significant gross lesions. Microscopically, microabscesses, hemorrhages, and perivascular cuffs were observed in the hindbrain along with positive immunostaining of intracellular L. monocytogens antigens in the mononuclear and polymorph nuclear cells. Two L. monocytogenes isolates (A4 and E7) from two goats had multiple antimicrobial-resistant indices ‎scores of 0.5 and 0.3 respectively which is above the Krumperman permissible threshold (>0.2), indicating a high-risk source of contamination by the resistant antibiotics in the study area. Encephalitic listeriosis was further confirmed through the 16sRNA molecular characterization and phylogenetic analysis of the two listeria isolates. Here we report two multidrug-resistant L. monocytogens isolates from goats in Oman, which pose a serious public health threat to both humans and animals.