previous page   Pak Vet J, xxxx, xx(x): xxx   next page
Evaluation of Possible Ameliorative Role of Robinetin to Counteract Polystyrene Microplastics Instigated Renal Toxicity in Rats
Muhammad Umar Ijaz1*, Akash Nadeem1, Muhammad Faisal Hayat1, Nazia Ehsan1, Khalid A Al-Ghanim2 and Usman Atique3

1Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad 38040, Pakistan
2Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Riyadh, Saudi Arabia
3College of Biological Systems, Chungnam National University, Daejeon 34134, South Korea
*Corresponding author:


This investigation was planned to determine the ameliorative potential of robinetin (RN) to counteract the adverse effects of polystyrene microplastics (PSMPs) on renal tissues. Twenty-four albino rats (Rattus norvegicus) were distributed into four groups i.e., control, PSMPs (0.01 mg/kg), PSMPs (0.01 mg/kg) + RN (50 mg/kg) and RN (50 mg/kg) only treated group. The activities of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione peroxidase (GPx) and glutathione reductase (GSR) were reduced while the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) were escalated following the PSMPs intoxication. Moreover, PSMPs exposure increased the levels of urea, creatinine, KIM-1 and NGAL while downregulating the levels of creatinine clearance. Furthermore, PSMPs markedly escalated the levels of NF-κB, IL-6, IL-1β, TNF-α and COX-2 activity. Besides, the levels of Caspase-3, Bax and Caspase-9 were elevated while levels of Bcl-2 were reduced after PSMPs intoxication. Additionally, PSMPs administration instigated various histopathological anomalies in renal tissues. Nonetheless, RN supplementation considerably restored aforementioned dysregulations instigated by PSMPs due to its antioxidative, anti-apoptotic and anti-inflammatory potential.

To Cite This Article: Ijaz MU, Nadeem A, Hayat MF, Ehsan N, Al-Ghanim KA and Atique U, 2024. Evaluation of possible ameliorative role of robinetin to counteract polystyrene microplastics instigated renal toxicity in rats. Pak Vet J.


ISSN 0253-8318 (Print)
ISSN 2074-7764 (Online)

SCImago Journal & Country Rank